2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione

Name	2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione
Synonyms	C527 2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione 2-(4-Fluorophenyl)-naphth[2,3-d]oxazole-4,9-dione Naphth[2,3-d]oxazole-4,9-dione, 2-(4-fluorophenyl)-
CAS	192718-06-2

Molecular Formula	C17H8FNO3
Molar Mass	293.25
Density	1.433±0.06 g/cm3(Predicted)
Boling Point	488.6±47.0 °C(Predicted)
Solubility	DMSO: soluble0.3mg/mL, clear (warmed)
Appearance	powder
Color	faint yellow to dark yellow
pKa	-4.21±0.20(Predicted)
Storage Condition	Sealed in dry,Room Temperature
In vitro study	Pretreatment of USP1/UAF1 with C527 resulted in inhibition of its enzyme activity with an IC 50 of 0.88±0.03 μM. C527 inhibits the DUB activity of the USP12/USP46 complex and other DUB enzymes in vitro . However, the IC 50 of C527 for these DUB enzymes was higher in comparison with USP1/UAF1 complex. C527 has considerably less inhibitory effect on UCH-L1 and UCH-L3, a different subclass of DUB enzymes. C527 treatments causes an increase in the levels of Ub-FANCD2 and Ub-FANCI. Pretreatment of cells with the C527 causes an enhancement in the cytoxicity of mitomycin C and camptothecin. C527 treatments lead to an increase in ubiquitinated forms of FANCD2 and FANCI, cause a decrease in homologous recombination activity, and sensitize cells to DNA damaging agents.

Hazard Symbols	Xn - Harmful
Risk Codes	22 - Harmful if swallowed
Safety Description	46 - If swallowed, seek medical advice immediately and show this container or label.
WGK Germany	3